Bioreactor-Fermentor

Fermentors, also known as bioreactors, are sterilised and enclosed vessels that are used for the growth of microorganisms under optimal conditions. The microorganisms can be grown in large quantities to produce metabolites for commercial uses.

Fermenter Application:
Animal vaccine production: Avian influenza vaccine, Porcine PRRS vaccine, Foot-and-mouth disease, Rabies vaccine, Mink vaccine, DTP vaccine, Diphtheria vaccine, Tetanus vaccine, etc.
Human vaccine production: Diphtheria vaccine, Tetanus vaccine, Meningitis vaccine, Pneumonia IV vaccine, Hepatitis B vaccine, etc.
Culture for microorganism (bacterial,fungi,yeast.etc), mammalian cell(293,CHO etc.), plant cell, algae, enzyme, protein, additives, antibiotics etc.

Description

Fermenter Description:

The main material is all stainless steel 316L tank body, there is no dead angle in the tank; it is equipped with special sampling and discharging valves for fermentation tanks, and transplanting pipes. It adopts a large viewing angle tank liquid level observation glass, 12V safety light, with temperature, PH, DO, deforming, liquid level interface, inoculation port, feeding port, and multiple spare ports. All welds are strong, neat and beautiful. The tank body is designed with optimized diversion, which improves the exchange efficiency and the uniformity of the temperature in the tank. One way of deep ventilation is adopted, and the rotameter shows that the gas flow is adjusted according to the process requirements, and the air distributor in the tank distributes the gas evenly; the sterilizing filter with a precision of 0.2 μm is used to prevent material backflow device, ensuring safety and greatly extending service life.

German Siemens S7-200 series PLC control system + 10” LCD touch screen display operation, on-site direct operation (menu type), full English menu and interface; sampling and display of tank data, browsing and analysis of system data, and reading settings. Available Control the stirring speed, the temperature of the medium in the tank, Ph value, DO value.

Parameter Description
Total volume 5L,10L,15L,20L,30L,50L,100L,200L,500L,1000L, 5KL, 50KL, 200KL etc.
Working volume 30%~70%
Tank Jacket tank, made by SS316 and SS304, tank design pressure 0.3Mpa, jacket design pressure 0.35Mpa, polishing 0.4-0.6um, ratio of diameter and height is 1:2.2-2.5
Stirring system Mechanical drive on the top/bottom or Magnetic drive on the top, 3pcs height adjustable six-blade paddle Stir speed: 50~1000rpm/50-400rpm
Sterilization Sterilize in place(SIP), auto control by program
Clean Clean in place (CIP) by spray ball
Gas control Control by rotor meter, air flow 1 vvm
Feeding Automatically feeding by peristaltic pump
Anti-foam control Automatically add antifoam by peristaltic pump
Temperature control Auto-control,  electric heating range: water source add 5℃ to 70℃
PH control PH 2.00-12.00±0.1, auto-control adding acid/base by peristaltic pump, pH sensor from Hamilton/Mettler, Switzerland.
Do control 0-150±3% displaying precision 0.1%, DO sensor from Hamilton/Mettler, Switzerland. DO coupling with agitation, oxygen.
Sampling Sampling valve, can sterilization separately, manual
Harvest Zero dead zone bottom valve(Gemu/Burket,Germany), can sterilization separately, manual/auto
Lid lift system 30L-500L have lid lift system, 700-1000L have human hole.
Pressure Auto control, BD Germany pressure transmitter
Exhaust Have condenser before exhaust, control by diagram valve / Proportional control valve.
Control parameters 10 or 15 inch touch screen , Siemens PLC with control parameters (stirring, pH, DO, temperature, feeding, alarm, gas etc.), data analysis, data record, data output, language(RU/EN/CN) and other customized functions
Optional configuration Remote control, Mass flow meter(auto control gas), O2/N2/CO2, gas flow 2vvm, gas(CO2) exhaust analysis, Level sensor, Turbidity(OD) sensor, ORP sensor, Weight system, Live cell sensor(Biomass), Printing, Siemens touch screen, Double mechanical seal, 4-Valves-group for feeding, Bottom valve auto discharge, ASME certificate, CSA certificate, Batch culture, Seed transfer, etc.

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